NaltrexLow™ Questions & Answers

How does NaltrexLow™ - LDN work?

Endorphins (feel-good molecules) are produced in most cells in the body and are important regulators of cell growth and the immune system. Disorders of the immune system can occur when endorphins are at unusually low levels.

Low dose naltrexone is a drug that binds to the body’s natural opiate ( endorphin) receptors for a short time. The body, feeling starved of natural endorphins (opiates), is now tricked to significantly increase its production of endorphins. Once the low-dose naltrexone stops blocking the opiate receptors (usually in 2- 3 hours), the body is then able to benefit from the hugely increased levels of endorphins circulating in the bloodstream. This is known as “the rebound effect”.

The benefits of the rebound effect can only be utilized by taking a low dose of regular naltrexone. Taking a high dose of naltrexone or using a slow-release formulation will continue to block the opioid receptors and no benefit can be achieved from the elevated endorphin levels.Individuals vary in their metabolic speed and this will result in variations of the speed at which LDN is eliminated from the body, as well as the length of the rebound effect.

A single daily dose of between 3 mg and 4.5 mg works well for most people, however some people benefit from building up their dose slowly or taking even two doses daily.



How quickly does NaltrexLow™ - LDN work?

Some patients experience a very fast response to LDN; immediately or within days of taking it. In many cases, the response becomes evident after about two weeks of use. In some cases, especially those of long standing chronic conditions, it has taken up to two months for benefit to accrue. LDN doesn’t work for everyone, however it is a very safe drug - so it is reasonable to wait up to 2 - 3 months to assess the intensity of its effect.


When should I take NaltrexLow™ - LDN?

Although many people take LDN in the evening or before sleep, scientific studies have shown that it is equally effective if taken during the day. This is important for those people who sometimes experience sleep disturbances as result of LDN.


Which medications must be avoided when using NaltrexLow™ (LDN)?

LDN should not be combined with any opiate-based drugs, as LDN can cancel their effects. Many painkillers are opiate-based. Drugs such as Imodium® are also opiate-based and LDN may neutralize its effect.


What are the side effects of NaltrexLow™ (LDN)?

Side effects from LDN are unusual. Sleep disturbances sometimes happen during the first few days of use, if taken at night. This can be avoided by taking it earlier in the day. Vivid dreams are reported more frequently. Low dose naltrexone is considered safe and non-toxic.


Can I use NaltrexLow™ (LDN) while pregnant or breastfeeding?

The use of any medicinal product during pregnancy or breastfeeding should be discussed with your physician.

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